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Dosage Forms & Strengths

tablet: Schedule IV

  • 2mg
  • 5mg
  • 10mg

oral solution: Schedule IV

  • 1mg/1mL
  • 5mg/mL

rectal gel: Schedule IV

  • 2.5mg
  • 10mg
  • 20mg

injectable solution: Schedule IV

  • 5mg/mL

intramuscular device: Schedule IV

  • 5mg/mL


2-10 mg PO q6-12hr, OR 2-10 mg IV/IM q6-12hr; no more than 30 mg/8 hours

Alcohol Withdrawal

10 mg PO q6-8hr during the first 24hr; reduce to 5 mg PO q6-8hr PRN

Initial: 10 mg IV/IM, may give additional doses of 5-10 mg IV q6-8hr as needed


IV: Titrate dose to 10 mg or less immediately before procedure, not to exceed the cumulative dose of 20 mg; reduce the dose of narcotic by one third or omit, OR

IM: 5-10 mg 30 minutes before the procedure

Preoperative Sedation

10 mg IM before surgery

Sedation in the ICU

5-10 mg IV 1-2 hours before surgery; 0.03-0.1 mg/kg q30min to 6hr

Muscle Spasm

2-10 mg PO q6-8hr PRN, OR 5-10 mg IV/IM initially; THEN q3-4hr if necessary

Seizure Disorder

2-10 mg PO q6-12hr as an adjunct, OR

0.2 mg/kg PR, repeat after 4-12 hours PRN

Status Epilepticus

5-10 mg IV/IM q5-10min; not to exceed 30 mg, OR

0.5 mg/kg PR (using parenteral solution), THEN 0.25 mg/kg in 10 minutes PRN  

Dosage Modifications

Renal impairment: No dose adjustment recommended unless administered for a prolonged period; decrease dose in prolonged periods

Hepatic impairment: 50% of a  maintenance dose

Seizures (Orphan)

Orphan designation for management of acute repetitive seizures or for Dravet syndrome by various administrative routes (eg, intranasal, buccal soluble film, or SC)


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