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dexedrine

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Uses

This medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Dextroamphetamine belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.

This medication is also used to treat a certain sleeping disorder (narcolepsy) to help you stay awake during the day. It should not be used to treat tiredness or to hold off sleep in people who do not have a sleep disorder.

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How does this medicine work? What are its effects ?

Dexamphetamine belongs to the family of medications called  stimulants . This medication is prescribed for the  treatment of attention deficit hyperactivity disorder (ADHD)  and  narcolepsy  (sleep attacks). It effectively treats narcolepsy by exerting a stimulating action on the brain. The way it helps people with ADHD has not been established yet.

Other measures (eg psychological, educational and social treatments) are used in conjunction with dexamphetamine and are an integral part of the ADHD treatment program.

Your doctor may have suggested this medicine for a condition not listed in this drug information article.  In addition, some forms of this drug may not be used for all the disorders mentioned in this article. If you have not discussed it with your doctor yet, or if you are not sure why you are taking this medicine, check it out. Do not stop taking this medicine without first consulting your doctor.

Do not give this medicine to anyone, even someone who has the same symptoms as yours.  This medicine may be harmful to people for whom it has not been prescribed.

How should this medication be used?

Treatment should start at the lowest possible dose and then increase gradually. For narcolepsy, the daily dose may vary between 5 mg and 60 mg, depending on the individual response. For attention deficit hyperactivity disorder, the daily dose may vary between 2.5 mg and 40 mg for a better response. Dexamphetamine is not recommended for children under 6 years of age.

The timing of taking this medication is very important. In principle, a long-acting formulation of the drug should not be taken in the evening because its effects could disturb sleep.

There are several factors that can be taken into consideration when determining the dose a person needs: weight, health, and other medications. If your doctor has recommended a dose other than those listed here,  do not change the way you take the medicine without first consulting.

It is important to use this medicine as directed by your doctor. If you miss a dose, take the medicine as soon as you notice the omission and resume the treatment as soon as possible. If it is almost time for your next dose, do not worry about the missed dose and go back to the usual dosing schedule. Do not use a double dose to compensate for a missed dose.  If you are unsure of what to do after you miss a dose, ask your doctor or pharmacist for advice.

Store this medication at room temperature, away from light and moisture and out of the reach of children.

Do not dispose of medicines in waste water (eg, in the sink or in the toilet bowl) or in household waste. Ask your pharmacist how to get rid of unused or expired medications.

In what forms does this medicine occur?

Spansule Capsules (Extended Release Capsules)

10 mg
Each cone-length, brown-tipped, natural-colored, conical, sustained-release capsule containing 2-tone, orange-colored pellets, monogrammed “3513” on the cap and bearing the “10 mg” and “SB” markings on the body. white ink, contains 10 mg of dexamphetamine sulfate. It releases a therapeutic dose quickly and maintains the effect for 10 to 12 hours by releasing the rest of the active ingredient gradually. Non-medicinal ingredients : cetyl alcohol, brilliant blue FCF, D and C yellow No. 10, ethylcellulose, gelatin, hydroxypropyl methylcellulose, sun yellow FCF, brilliant blue aluminum lake FCF, sodium lauryl sulphate, povidone, propylene glycol, red allura AC, dibutyl sebacate, silica , spheres of sugar and traces of other inactive ingredients.

15 mg
Each cone-length, brown-tipped, natural-colored, conical, sustained-release capsule containing 2-tone, orange-colored pellets, monographed “3514” on the cap and bearing the “15 mg” and “SB” markings on the body. white ink, contains 15 mg of dexamphetamine sulfate. It releases a therapeutic dose quickly and maintains the effect for 10 to 12 hours by releasing the rest of the active ingredient gradually. Non-medicinal ingredients : cetyl alcohol, brilliant blue FCF, D and C yellow No. 10, ethylcellulose, gelatin, hydroxypropyl methylcellulose, sun yellow FCF, brilliant blue aluminum lake FCF, sodium lauryl sulphate, povidone, propylene glycol, red allura AC, dibutyl sebacate, silica , spheres of sugar and traces of other inactive ingredients.

tablets

5 mg
Each orange, equilateral triangle-shaped tablet with rounded corners and a scored mark, and the Paladin shield logo, contains 5 mg of dexamphetamine sulfate. Nonmedicinal ingredients: stearic acid, starch, gelatin, sun-yellow FCF, lactose, sucrose, calcium sulfate, talc, and tartrazine.

In which cases is this medicine not recommended?

Refrain from using dexamphetamine under the following circumstances:

  • a heart condition
  • are allergic to other drugs of the same class
  • is allergic to dexamphetamine or to any of the ingredients of the medication
  • a personal or family history of Gilles de la Tourette syndrome.
  • a history of drug abuse;
  • hardening of the arteries at an advanced stage;
  • a state of agitation;
  • glaucoma (a rise in pressure in the eye)
  • the presence of motor tics;
  • moderately to severely high blood pressure
  • overactivity of the thyroid gland (hyperthyroidism);
  • if you are anxious or tense.

This medication should not be used at the same time or within 14 days of taking MAO inhibitors such as phenelzine or tranylcypromine.

What are the possible side effects of this medicine?

Many medications can cause side effects. A side effect is an undesirable response to a drug when taken at normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not felt by everyone who takes this medicine. If you are worried about side effects, discuss the risks and benefits of this medicine with your doctor.

At least 1% of people taking this medication have reported the following side effects. Many of these side effects can be taken care of and some can go away on their own with time.

Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects occur:

  • an upset stomach
  • dizziness
  • irritability or mood swings;
  • headaches;
  • loss of appetite
  • a dry mouth, an unpleasant taste in the mouth;
  • tremors;
  • sleep disorders.

Most of the side effects listed below do not occur very often, but they could still cause serious problems if you do not receive medical care.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abnormalities of the visual field;
  • anxiety;
  • swelling of the legs with shortness of breath
  • changes in behavior
  • palpitations (the feeling that your heart beats faster or irregularly than usual);
  • abnormal thoughts or behavior, hallucinations or irrational beliefs;
  • high blood pressure
  • a slowdown in growth;
  • symptoms attributable to Raynaud’s syndrome (eg, discoloration, coldness, numbness of the fingers or toes)
  • symptoms of depression (eg, disinterest in your usual activities, sadness, suicidal thoughts)

Stop taking the medication and seek immediate medical attention if there is an answer such as:

  • convulsions
  • self-destructive or suicidal thoughts;
  • symptoms of a serious allergic reaction (eg, hives, swelling of the face and throat, difficulty breathing)

Some people may experience side effects other than those listed. Consult your doctor if you notice a symptom that worries you while you are using this medicine.

Are there other precautions or warnings?

Before using any medication, be sure to tell your doctor about any medical conditions or allergies you may have, medications you are using, and other important things about your health. Women should mention if they are pregnant or breastfeeding. These factors could affect how you should use this medicine.

HEALTH CANADA NOTICE

[March 30, 2015]

Health Canada has issued new warnings regarding the use of drugs for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). To read Health Canada’s full notice, visit Health Canada’s website at www.hc-sc.gc.ca .

Allergies: Products containing dexamphetamine contain atrazine, which can cause allergic-type reactions (including bronchial asthma). People allergic to salicylates are often allergic to tartrazine. Talk to your doctor about the risks and benefits of this medicine.

Drowsiness / reduced alertness: This medication may mask extreme fatigue that may impair the ability to carry out potentially hazardous activities, such as driving a vehicle or operating machinery. If the medicine works on you in this way, avoid driving or performing tasks requiring alertness.

Drug dependence: It is possible that some people make excessive use of dexamphetamine. Tolerance, extreme psychological dependence and severe social maladjustment can ensue. If you have a history of alcohol or drug dependence, your doctor should monitor your condition closely while you are taking this medication.

Physical Activity: People who engage in strenuous exercise or other strenuous physical activity should consult their physician before taking dexamphetamine.

Heart problems : this medicine can increase heart rate and raise blood pressure. It can also increase the risk of sudden death in people with heart problems. Physicians with heart problems, such as irregular heartbeat or a family history of sudden death from heart disease, should perform tests to assess their health before prescribing this medication. Then they should be subject to strict medical supervision if they take the medicine. This medication should generally not be used by people who have a family history of sudden death or death from heart disease, pre-existing structural heart abnormalities (such as missing heart valves,

High Blood Pressure: This medication may cause a rise in blood pressure. If your blood pressure is high or you have heart problems, talk to your doctor before taking this medicine.

Long-term use: If you use this medicine for a long time, you will have to undergo cardiac exams and laboratory tests regularly.

Psychiatric issues: tell your doctor about any mental health issues you have, or have, your child with; tell them about family history of bipolar disorder, depression or suicide. This medication may increase the risk of mental health problems (psychiatric disorders). These may be new or signs of worsening behavior and disturbing thoughts, bipolar disorder, depressive mood, aggressive and hostile behavior. Children and adolescents may also have new psychotic symptoms (eg, paranoia or hallucinations) or new symptoms of mania (eg, irrational beliefs, hyperactivity). If you observe these types of symptoms while using dexamphetamine,

Seizures: The use of dexamphetamine may increase your risk of convulsions, especially if you have had one. If you have a history of convulsion or convulsive disorder, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and how often this medication affects you. relevance of specific medical surveillance.

Stopping the drug: People who suddenly stop taking this medication sometimes experience trouble sleeping, extreme tiredness and depression. Consult your doctor before stopping this medication.

Suicidal or agitated behavior: People taking this medication may experience restlessness (impatience, anxiety, aggression, strong emotions and feelings of not being themselves), or they may want to to hurt or hurt someone. These symptoms may occur at any time during treatment with this medication, although they are most commonly seen at the beginning of treatment or during dose increases. If you experience these side effects or if you think they affect a family member who is taking this medicine, contact your doctor immediately. While taking this medication, your doctor should monitor you closely to detect emotional and behavioral changes.

Stunting: Growth suppression (a smaller or larger increase in size or weight) has been reported in some children who have used stimulants such as dexamphetamine for prolonged periods of time. It is not known if the drug is causing the blockage of growth. Special monitoring of children’s growth is needed when they need long-term treatment. Their doctor may recommend a “therapeutic window” when the drug is not given on weekends or during school holidays.

Vision: People who took dexamphetamine rarely had visual field defects. If your vision changes a little, contact your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If pregnancy occurs while you use this medicine, contact your doctor immediately.

Breastfeeding  : This medication passes into breast milk. If you use dexamphetamine while you are breastfeeding, your baby may feel the effects. Consult your doctor to find out if you should continue breastfeeding. Mothers taking dexamphetamine should not breastfeed.

Children: The safety and effectiveness of this medication have not been established for children under 6 years of age.

Can other agents interact with this medicine?

There may be an interaction between dexamphetamine and any of the following:

  • acetazolamide;
  • urinary acidifiers (eg ammonium chloride) and alkalizing agents (eg potassium citrate);
  • alkaloids of ergot (eg ergotamine, dihydroergotamine);
  • serotonin antagonists (anti-emetic drugs, eg granisetron, ondansetron);
  • antacids (eg aluminum hydroxide, calcium carbonate, magnesium hydroxide);
  • tricyclic antidepressants (eg, amitriptyline, clomipramine, desipramine, trimipramine)
  • antihistamines (eg cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (eg, chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • atomoxetine;
  • other drugs used to treat ADHD (eg atomoxetine, methylphenidate, lisdexamphetamine);
  • barbiturates (eg phenobarbital);
  • beta-blockers (eg, propranolol)
  • sodium bicarbonate;
  • bromocriptine;
  • long-acting bronchodilators (eg formoterol, salmeterol);
  • fast-acting bronchodilators (eg, salbutamol, terbutaline)
  • the buspirone;
  • the cabergoline;
  • caffeine;
  • cyclobenzaprine;
  • desvenlafaxine;
  • dextromethorphan;
  • dipivefrin;
  • dronabinol;
  • epinephrine;
  • ethosuximide;
  • ophthalmic drops and decongestant nasal sprays (eg naphazoline, oxymetazoline, xylometazoline);
  • hydrochlorothiazide;
  • hypotensives;
  • MAO inhibitors (MAOIs eg moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine);
  • proton pump inhibitors (eg, lansoprazole, omeprazole)
  • selective serotonin reuptake inhibitors (SSRIs, eg, citalopram, duloxetine, fluoxetine, paroxetine, sertraline);
  • selective serotonin-noradrenaline reuptake inhibitors or ISRNs (eg desvenlafaxine, duloxetine, venlafaxine);
  • linezolid;
  • lithium;
  • antimigraine drugs of the “triptan” class (eg, eletriptan, sumatriptan);
  • decongestant medications (eg, phenylephrine, pseudoephedrine)
  • methadone;
  • methenamine;
  • St. John’s wort;
  • multivitamins and mineral supplements;
  • nabilone;
  • analgesic narcotics (eg, codeine, fentanyl, morphine, oxycodone);
  • nefazodone;
  • phenytoin;
  • tapentadol;
  • topiramate;
  • tramadol;
  • trazodone;
  • tryptophan;
  • venlafaxine;
  • vitamin C.

If you are taking any of these medicines, consult your doctor or pharmacist. In your case, your doctor may ask you to:

  • stop taking one of the medications
  • replace one drug with another
  • change the way you take one or both medications
  • do not change anything at all.

The interference of one drug with another does not always result in the interruption of taking one of them. Ask your doctor what to do in case of drug interactions.

Other medicines than those listed above may interact with this medicine. Tell your doctor everything you are taking, whether prescription or over-the-counter medications and herbal remedies. Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine or illegal drugs, you should tell your prescribing doctor as these substances may affect the action of many medicines.

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